MK-4101

MK-4101

【产品别名】MK 4101, MK4101

【CAS号】 935273-79-3

【目录编号】 2H-50

【纯度】 98%

【分子式】 C24H24F5N5O

【分子量】 493.47

【简介】 MK-4101 is a potent SMO Inhibitor of the Hedgehog Pathway

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MK-4101 详细介绍

MK-4101 is a potent SMO Inhibitor of the Hedgehog Pathway, highly active against Medulloblastoma and Basal Cell Carcinoma. target:SMO In vivo: MK-4101 was highly efficacious against primary medulloblastoma and BCC developing in the cerebellum and skin of Ptch1+/- mice. In vitro: MK-4101 induce deregulation of cell cycle and block of DNA replication in tumors. MK-4101 targets the Hh pathway in tumor cells, showing the maximum inhibitory effect on Gli1. MK-4101 also induce deregulation of cell cycle and block of DNA replication in tumors.

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