OICR-9429

OICR-9429

【产品别名】OICR9429, OICR 9429

【CAS号】 1801787-56-3

【目录编号】 2H-47

【纯度】 98%

【分子式】 C29H32F3N5O3

【分子量】 555.59

【简介】 OICR-9429 is a novel small-molecule antagonist of the Wdr5-MLL interaction with IC50 of 5 uM. inhibit proliferation and induce differentiation .

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OICR-9429 详细介绍

OICR-9429 is a novel small-molecule antagonist of the Wdr5-MLL interaction with IC50 of 5 uM. inhibit proliferation and induce differentiation . target: Wdr5 IC 50: 5 uM In vitro: OICR-9429 inhibit proliferation and induce differentiation in p30-expressing human AML cells. OICR-9429 cause a significant decrease in viability in the majority of patient cells with mutations in the N-terminal part of the CEBPA gene. OICR-9429 displays exquisite cellular selectivity and specificity in disrupting critical protein-protein interactions between WDR5. [1] reduce the viability of primary human AML cells with N-terminal C/EBPα mutations by about 50% (mean value, n = 8) at 5 μM [2] In vivo:The reference for OICR-9429 to mice (female NOD-SCID) is 3 mg/kg.

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