GNE-3511

GNE-3511

【产品别名】GNE3511; GNE 3511

【CAS号】 1496581-76-0

【目录编号】

【纯度】 98%

【分子式】 C₂₃H₂₆F₂N₆O

【分子量】 440.49

【简介】 GNE-3511 is a potent and selective zipper kinase (DLK, MAP3K12) inhibitors.

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GNE-3511 详细介绍

GNE-3511 is a potent and selective zipper kinase (DLK, MAP3K12) inhibitors.
target: DLK, MAP3K12;
IC50: 0.107 uM (DLK);
In vitro: . The high dose of inhibitor GNE-3511 resulted in a completesuppression of c-Jun phosphorylation, while the low dose reduced the number of p-c-Jun positive cells to an intermediate level. protected primary neurons in an in vitro axon degeneration assay as well as reduced phosphorylation of the downstream transcription factor c-Jun.
In vivo: GNE-3511 exhibites moderate (mouse, rat, and cynomolgus) to high (dog) in vivo plasma clearances, moderate volumes of distribution, short half-lives, and brain penetration sufficient to enable examination in animal models of neurodegeneration.

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