ETP-46321

ETP-46321

【产品别名】ETP46321;ETP 46321

【CAS号】 1252594-99-2

【目录编号】

【纯度】 98%

【分子式】 C₂₀H₂₇N₉O₃S

【分子量】 473.55

【简介】 ETP-46321 is a potent and orally bioavailable PI3K α/δ inhibitor with IC50 of 2.3/14.2 nM for p110α/p110β; exhibits potency on mutated p110α(IC50=1.77-2.33 nM, p110a E542K; E545K; H1047R).

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ETP-46321 详细介绍

ETP-46321 is a potent and orally bioavailable PI3K α/δ inhibitor with IC50 of 2.3/14.2 nM for p110α/p110β; exhibits potency on mutated p110α(IC50=1.77-2.33 nM, p110a E542K; E545K; H1047R).
IC50 value: 2.3/14.2 nM(p110α/p110β)
Target: PI3K α/δ inhibitor
ETP-46321, has been pro?led and shown to be a potent PI3K a and d inhibitor, highly selective versus mTOR and 288 representative kinases. The compound demonstrated a good pharmacokinetic profile in mice and was selected for preliminary in vivo evaluation in a lung tumor mouse model driven by a K-Ras G12V oncogenic mutation, showing significant tumor growth inhibition (ca. 51%), and reduction of the tumor metabolic activity as measured by PET techniques.

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