Mivebresib

Mivebresib

【产品别名】ABBV-075; ABBV075; ABBV 075

【CAS号】 1445993-26-9

【目录编号】 2H-52

【纯度】 >98%

【分子式】 C22H19F2N3O4S

【分子量】 459.47

【简介】 Mivebresib, a novel BET family inhibitor, disrupts critical transcription programs that drive prostate cancer growth to induce potent anti-tumor activity in vitro and in vivo.

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Mivebresib 详细介绍

Mivebresib, a novel BET family inhibitor, disrupts critical transcription programs that drive prostate cancer growth to induce potent anti-tumor activity in vitro and in vivo. Also a potent inhibitor of MYC and the TMPRSS2-ETS fusion proteins target: BET, MYC In vitro: Mivebresib inhibit DHT-stimulated transcription of AR target genes without significant effect on AR protein expression. In addition to blocking the transcription activation downstream of AR, Mivebresib is also a potent inhibitor of MYC and the TMPRSS2-ETS fusion proteins.

References

[1]. EJ Faivre et al. Abstract 4694: ABBV-075, a novel BET family inhibitor, disrupts critical transcription programs that drive prostate cancer growth to induce potent anti-tumor activity in vitro and in vivo

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