MCC950 sodium

MCC950 sodium

【产品别名】MCC950 , CP-456773

【CAS号】 256373-96-3

【目录编号】 2H-35

【纯度】 >98%

【分子式】 C20H23N2NaO5S

【分子量】 426.46

【简介】 MCC950 (CP 456773) sodium is a potent, selective, small molecule inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs

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MCC950 sodium 详细介绍

MCC950 blocked canonical and noncanonical NLRP3 activation at nanomolar concentrations.
MCC950 specifically inhibited activation of NLRP3 but not the AIM2, NLRC4 or NLRP1
inflammasomes. MCC950 reduced interleukin-1β (IL-1β) production in vivo and attenuated the
severity of experimental autoimmune encephalomyelitis (EAE), a disease model of multiple
sclerosis. 

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